FLUCONAZE 150

Properties:

Fluconaze 50 50mg/ Capsule

Fluconaze 150 150mg/ Capsule

Fluconaze 200 200mg/ Capsule

Fluconaze is a selective broad spectrum bis-triazole anti-fungal drug; it inhibits fungal cytochrome P-450 and prevents ergosterol synthesis.

Indications:

Fluconaze is used in the treatment of:

Oropharyngeal and esophageal candidiasis.

Systemic candidal infections including peritonitis, pneumonia and vaginal candidiasis. Cryptococcal meningitis.

It is used for the prophylaxis of fungal infection in immune-compromised patients such as AIDS patients.

Contraindications:

Hypersensitivity to fluconazole or to any derivatives. There is no information regarding cross hypersensitivity between fluconazole and other antifungal agents.

Side effects:

Nausea, vomiting, diarrhea, headache, skin rash, abdominal pain, and elevated liver function values. Drug interactions:

Cimitidine and rifampicin decrease serum concentrations of Fluconaze.

Fluconaze may interfere with oral contraceptive drugs.

Fluconaze increases the serum concentration of oral antidiabetes drugs, causing low blood sugar, so blood glucose concentrations should be monitored and the dose should be adjusted as necessary.

Fluconaze increases prothrombin time after receiving warfarin, so prothrombin time should be monitored especially in patients receiving coummarin-type anticoagulants. Fluconaze increases serum concentrations of pheytion, cyclosporin, and theophyllin. Precautions:

In rare cases, anaphylaxis has been reported.

Hepatic injury patients who develop abnormal liver function tests during Fluconaze therapy should be monitored for the development of more sever hepatic injury, Fluconaze should be discontinued if clinical symptoms of liver diseases has been developed.

Closely monitor immune compromised patients (espeully AIDS patients) who develop rashes and discontinue the drug if lesions progress.

Pregnancy: there is no adequate controlled studies in pregnant woman, tell your doctor if

you are pregnant or thinking of becoming pregnant.

Lactation: Fluconaze passes into breast milk, so avoid it during lactation.

Dosage & Administration:

The dose of Fluconaze depends on the type of fung and on the paiteint response to therapy, treatment should be continued until clinical and laboratory parameters subside.

The recommended dosage of Fluconaze for:

Oropharyngeal and esophageal candidiasis is 200mg on the first day, followed by 100mg once daily, treatment should be continued for at least 2 weeks, followed by further two weeks treatment after healing.

Vaginal candidiasis: 150mg daily, as a single dose.

Systemic candidiasis: 400mg on the first day, followed by 200mg daily for 28 days at least, followed by further 2 week treatment after healing.

Acute cryptococcal meningitis: 400mg on the first day, followed by 200mg daily treatment should be continued for (10-12) weeks after negative culture of cerebrospinal fluid. In patient with impaired renal function, an initial loading does of (50 – 400) mg should be given; after the loading does. The daily does should be based on the following table: 

Storage:

– Store in a cool & dry place below 25°C –

Keep out of reach of children

Presentation:

Fluconaze 50: 1 blister contains 10 capsules carton box.

Fluconaze 150: 1 blister contains 10 capsules carton box.

 Fluconaze 200: 1 blister contains 10 capsules carton box.