CYPROVITAMINE

Composition:

Each 5 ml of CYPROVITAMINE syrup contains:

Cyproheptadine HCL …… 4 mg Vitamin B1  Vitamin B2.

Properties:

0.6 mg 0.75 mg  Vitamin B6 Vitamin C  0.67 mg  Niacinamide…… 6.67 mg 21.67 mg

Cyproheptadine HCL is a histamine H1-receptor antagonist and serotonin antagonist.

Vitamin C is essential for the synthesis of collagen and intercellular material. Vitamin B1 (Thiamine) is an essential coenzyme for carbohydrate metabolism. Vitamin B2 (Riboflavin) is essential for utilization of energy from food. Vitamin B6 is involved mainly in aminoacid metabolism. It is also involved in carbohydrate and fat metabolism. It is required for the formation of hemoglobin.

Niacinamide in the form of NAD and NADP Coenzymes is involved in electron transfer reactions in the respiratory chain.

Indications:

CYPROVITAMINE syrup is indicated in symptomatic relief of

hypersensitivity reactions including urticaria, angioedema, rhinitis and conjunctivitis, and in pruritic skin disorders.

CYPROVITAMINE syrup is used for appetite stimulation especially in anorexia nervosa.

The adjunction of the Vitamins to cyproheptadine HCL prevents development of Vitamin deficiencies.

Side effects of antihistamines:

Antimuscarinic effects: Dry mouth, thickened respiratory, tract secretions and tightness of the chest, blurred vision, urinary difficulty, and reduction in motility of gastrointestinal tract resulting in constipation and increased gastric reflux; in high doses transient bradycardia followed by tachycardia with arrhythmias.

Overdosage:

In adults CNS depression is more common with drowsiness, coma and convulsions progressing to respiratory failure or cardiovascular collapse.

Treatment of overdose effects:

The stomach should be emptied immediately, then; activated charcoal should been given.

Precautions for H1-receptor antagonists (antihistamines):

Antihistamines should not be given to premature infants or neonates or elderly patients since they have increased susceptibility to antimuscarinic effects. Patients on antihistamine treatment should not drive or operate machinery. They should avoid alcoholic drinks.

Vitamin administration adverse effects/ precautions to be taken: Large doses of Vitamin C are reported to cause diarrhea and other gastro- intestinal disturbances it may also result in hyperoxaluria and the formation of renal calcium oxalate calculi.

Interactions of antihistamines:

Antihistamine may enhance the sedative effects of CNS depressants: alcohol, barbiturates, hypnotics, opioid analgesics anaxiolytic sedatives and neuroleptics. Pregnancy and Lactation:

It should be used only under physician supervision.

Contraindications:

Antihistamines should be used with precaution in closed angle-glaucoma, urinary retention, prostatic hypertrophy, or pyloroduodenal obstruction, asthma, epilepsy, severe cardiovascular disorders; liver disorders with MAOI. Dosage and Administration:

It should not be used for children under 2 years of age.

Children (2 to 6) years: 2.5 ml twice daily.

– (7 to 14) years and Adults: 5 ml three times daily.

– Appetite stimulant: Doses from the lower end of each dose range have been used to stimulate the appetite.

Presentation:

Glass bottle of 100ml CYPROVITAMINE syrup/ carton box.

Storage Conditions: Store below 30°C Keep out of reach of children.